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人成纖維細胞生長因子10 Elisa試劑盒
物品單位 價格 品牌
2600 Solarbio
  • 產地:北京
  • 貨號:SEKH-0425
  • 發布日期: 2020-08-10
  • 更新日期: 2020-08-10
產地 北京
保存條件 -20
品牌 Solarbio
貨號 SEKH-0425
檢測方法 雙抗體夾心法
適應物種 Human
檢測限 31.2 - 2000 pg/mL
數量 999
用途范圍 Human
純度 %
樣本 血清/血漿/細胞培養上清
應用 Elisa試劑盒
The Fibroblast Growth Factors (FGFs) are heparin binding glycoproteins that exert a variety of biological activities toward cells of mesenchymal, neuronal, and epithelial origin. FGF-10 belongs to the subgroup of FGFs that also includes FGF-3, -7, and -22. Mature human FGF-10 is an approximately 20 kDa protein that contains a serine-rich region near its N-terminus. It shares 93% and 96% amino acid sequence identity with mouse and rat FGF-10, respectively. FGF-10 is secreted by mesenchymal cells and associates with?extracellular FGF-BP. It preferentially binds and activates epithelial cell FGF?R2 (IIIb) and interacts more weakly with FGF?R1 (IIIb). The mitogenic and chemotactic properties of FGF-10 are critical in many tissues during embryogenesis. This includes limb bud initiation, palate development, branching morphogenesis and directional outgrowth of lung buds, formation of the otic vesicle and chochlea, adipogenesis, and the development of prostate, mammary, lacrimal, and submandibular salivary glands. FGF R2 (IIIb) signaling in these responsive tissues is similarly important during embryogenesis. The expression and function of FGF-10 are negatively regulated by Shh and BMP-4 in the developing lung. Overlapping expression patterns and activities with FGF-3, -7,?and -8 suggest at least a partial redundancy in FGF?10 biology. FGF-10 induced signaling through FGF R2 (IIIb) also contributes to the progression of pancreatic cancer.
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